Latin Names: Tripterygium wilfordii

Thunder god vine is belong to perennial, which is commonly grown in the southeast China. It has been used for hundreds of years in TCM. Currently, the thunder god vine is promoted for use orally (by mouth) for rheumatoid arthritis, multiple sclerosis, Crohn’s disease, lupus, psoriasis, fever etc.. It is also promoted for use topically (applied to the skin) for rheumatoid arthritis.

Tripterygium wilfordii also have a history of anti-inflammatory, immunosuppressive, and antitumor effects. Its mechanism of action is relatively complex, and can act on various stages of inflammatory response, such as inhibiting inflammatory cells and inhibiting inflammatory cytokines. It also has an effect on immunosuppression, which can inhibit lymphocytes and neutrophils, so it is conducive to the suppression of immune response.

1. Anti-inflammatory: It has been reported that the monomeric components of tripterygium wilfordii with immunomodulatory and anti-inflammatory effects include tripterygiine, tripterygiine amyl, demethylzelaldehyde and relactone, etc. Triptolide treatment can reduce the expression of TNF-α-induced phosphorylated JNK, reduce RAFLS migration, inhibit the TLR4-induced NF-κB/IL-1β immune pathway, inhibit the NF-κB/TNF-α/VCAM-1 inflammatory pathway, and regulate the TGF-β1/α-SMA/ waveform fibrosis pathway. Thus, it plays a therapeutic role in rheumatoid arthritis and dilated cardiomyopathy.

2. Immunosuppressive effect: As an immunosuppressant, Tripterygium wilfordii has been widely used in clinic and has a good effect on the treatment of rheumatoid arthritis, systemic lupus erythematosus, purpura, glomerular disease, Bercet's disease and other autoimmune diseases. The effect of Tripterygium Wilfordii on immunity was mainly reflected in the inhibition of cellular immunity and humoral immunity.

3. Anti-tumor effect: Tripterygium Wilfordii can exert anti tumor effects through its effects on cell cycle, angiogenesis, vascular endothelial growth factor, cell proliferation and apoptosis, protein expression and cell morphology, and can be used as potential clinical anticancer drugs.

4. Effects on neurodegenerative diseases: Tripterygium wilfordii extracts, tripterygium lactone, T10, T4, etc. have certain therapeutic effects on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, experimental autoimmune encephalomyelitis, cerebral ischemia, etc. The mechanism is generally to inhibit inflammatory response factors and promote the secretion of protective cytokines.

5. Antiviral effect: Tripterygfordii can inhibit Epstein-Barr virus, cytial rash virus type 1, measles virus, influenza type A virus, etc. The mechanism may be related to inhibiting viral protein synthesis, inhibiting viral gene transcription and viral nucleic acid synthesis. Tripterine inhibited HBV DNA replication in mouse primary hepatocytes by inhibiting HBsAg expression, and inhibited the transcription and replication process mediated by human immunodeficiency virus Tat-protein by anti-retroviral treatment.

The Thunder God Vine Extract provided by KINGHERBS LIMITED adopts a natural extraction method, which has no toxic and side effects, and is safer and more reliable.