The Effects of Andrographis Paniculata Extract


Andrographis paniculata extract is the extract of the dry aerial parts of the Acanthaceae plant Andrographspaniculata. The main active ingredient is Andrographolide. which has the effects of dispelling heat, detoxification, anti-inflammatory and relieving pain, and has special effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. Andrographis paniculata grows in hot and humid plains and hilly areas. Mainly produced in Guangdong and Fujian. At present, the warm area of theYangtze River from the north to the south has been introduced and cultivated.


The Efficacy and Role of Andrographis Paniculata

1. Clear Heat and Reduce Inflammation

It has a significant antipyretic effect on experimental fever and a significant inhibitory effect on experimental inflammation. The anti-inflammatory effect of Andrographis paniculata is related to the excitement of the pituitary adrenal cortex system. It has been clinically applied to a variety of infectious diseases, including trauma infection, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute and chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urine Road infections, endometritis, pelvic inflammatory disease, otitis media, periodontitis, etc. all have varying degrees of curative effect.


2. Antibacterial
The new andrographolide contained in Andrographis is clinically better than chloramphenicol and furazolidone on bacillary dysentery, and has no side effects and toxicity. In vitro tests, the water decoction of Andrographis paniculata and the crude crystals isolated from it can inhibit or kill certain types of Leptospira.The decoction has a certain inhibitory effect on pneumococcus, streptococcus alpha and catarrhalis.

3. Anti-snake Venom

Both the alcohol extract and water solution of Andrographis paniculata have obvious anti-rattlesnake venom effects. The main mechanism is that the extract of Andrographis paniculata has no effect on the activity of nicotinic receptors, but shows obvious muscarinic effects. Andrographis is used to treat various snake venoms.

4. Anti-virus

Andrographis paniculata decoction can delay the degeneration of human embryonic kidney cells caused by orphan virus ECHO11. Andrographis paniculata has certain anti-HIV effects in in vitro tests.


5. Protect Liver and Choleretics

Andrographolide has a significant antagonistic effect on liver injury, and can decrease serum ALT, ASTAKP, SB and intrahepatic triglycerides. Andrographolide also has significant choleretic effects.

6. Regulate Adrenal Cortex Hormones

Dehydrated andrographolide succinate half ester has the effect of reducing the content of vitamin C in the adrenal glands and It disappears completely after removal of the pituitary gland. DAS can not prolong the survival time of young rats with adrenal gland removal. It mainly stimulates the function of the anterior pituitary gland and promote the synthesis and release of ACTH, thereby enhancing the function of the adrenal cortex.

7. Immunosuppression

The influence of Andrographis paniculata on the immune function of the human body is very complicated.Water decoction, lactone injection, and A injection all enhanced the phagocytosis of mouse macrophages and peripheral leukocytes. The clinical efficacy of Andrographis paniculata in anti-infection may be related to this. Andrographolide can make mouse thymus atrophy, reduce peripheral T cells, reduce antibody tite in serum, and inhibit delayed-type hypersensitivity, which indicates that andrographolide has inhibitory effect on T cells and B cells, and is an immunosuppressant.


Main Specifications of Andrographolide from Kingherbs:

Andrographolide 3% / 5% / 10% / 20% / 30% / 50% / 80% /95% / 99%